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    Was it working?
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    While Preston played later in the backyard August sunshine, his eyes seemed to roar.
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    “Silly mommy,” he says quietly.
    So optimistic is Ana that, as Preston’s 13th birthday approaches, she makes a bold decision: It’s time for her son to get his first real bicycle.
    May 29 Jake Beckman concentrates on splitting a plant stem for cloning. The Stanley brothers have specialized in breeding high-CBD strains of cannabis, including Charlotte’s Web.
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    August 20 Ana Watson has decided to try adding THC to Preston’s CBD oil, which will change the ratio of doses she gives him.
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    Some epilepsies respond well to generalized anti-seizure drugs. But the specific genetic mutation of each Dravet patient is different, meaning what works for some won’t work for others. Preston has at least four different kinds of seizure types, and they varied in severity and frequency as he grew older.
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    So, one morning in mid-October, Ana Watson cues up Jason Aldean’s “Big Green Tractor” on her phone and hands it to her 12-year-old son, still in his pajamas. And then something magical happens.
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    Some physicians are now stepping forward to work with providers on clinical trials for CBD, and doctors at Children’s have begun recording more specific details of the CBD products their patients are using — who is providing the medical marijuana and how much the child is taking, for instance. But the broader dynamic still hinders the study of CBD’s effectiveness. And that only increases the uncertainty that hangs over families such as Ana’s in their Colorado exile.
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