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    “Silly mommy,” he says quietly.
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    One of those extreme cases is out of Orange County. Blake Zika, 22, has suffered from frequent seizures since he was four years old. His illness has left him developmentally challenged.
    Let’s use hemp to make paper and textiles. Let’s use cannabis to make our CBD medicine.
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    But no one knows more than anecdotes because Colorado does not track how many families come to treat their children with medical marijuana — although it’s in the low hundreds — or where they go.
    In a lab in Seattle, black mice twitch uncontrollably as they work their way through an electrified cage, furry little avatars of kids with Dravet syndrome...
    After sailing through Virginia's Senate, the House version of SB 1235 received a unanimous 98-0 vote in favor on Feb. 10. The bill prevents patients from being prosecuted for using cannabis oil for seizure-related con***ions. On Feb. 26, 2015, Democrartic Gov. Terry McAuliffe signed the bill into law, making Virginia the 12th state to legalize CBD oil.
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    In advance of the move, Ana reduced the dose of one of the three main seizure medicines he takes — a drug called Onfi — because she had heard from other parents that CBD amplifies it. He was now taking about a third less than what Greenwood had prescribed, although she didn’t tell the doctor her plan.
    “An uncontrolled experiment”
    CBD is one of more than 80 active cannabinoid chemicals in the marijuana plant.ii Unlike the main psychoactive cannabinoid in marijuana, tetrahydrocannabinol (THC), CBD does not produce euphoria or intoxication.iii,iv,v Cannabinoids have their effect mainly by interacting with specific receptors on cells in the brain and body: the CB1 receptor, found on neurons and glial cells in various parts of the brain, and the CB2 receptor, found mainly in the body’s immune system. The euphoric effects of THC are caused by its activation of CB1 receptors. CBD has a very low affinity for these receptors (100 fold less than THC) and when it binds it produces little to no effect. There is also growing evidence that CBD acts on other brain signaling systems, and that these actions may be important contributors to its therapeutic effects.ii
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    In her hand, Ana holds the first dose of what she hopes will finally stop the seizures. More than a dozen medicines have already failed, and continuing down the certain path of conventional treatments promises only more misery and maybe even death for Preston. So Ana has chosen uncertainty in the form of this amber oil created in a Boulder County garage.
    Ana’s reply is quiet.
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    October 8 Penn Mattison and Shawn McCafferty load tall holding racks with cannabis plants to be hauled to the drying warehouse during the Realm of Caring hemp harvest in eastern Colorado.
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