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    Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the two main ingredients in the marijuana plant.


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    So Ana visited her CBD provider, who gave her oil at a 10:1 ratio of CBD to THC, and the next day she watched as her son ate better than he had in months: a plate of fried okra, a plate of potato chips smothered in barbecue sauce, a stick of string cheese, a Frosty and, most surprising of all, tuna salad with crackers.
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    May 12 Preston spits out his seizure medications, which were mixed with sweet tea. He took the first few squirts easily, but as more of the undissolved pills filled the syringe, the taste and texture became much worse. Preston’s meds have been masked in everything imaginable — sweets, ice cream, whipped cream, ranch dressing — which he eats on almost everything. But all attempts are less and less effective.
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    “Is that the one that causes the rash?” Ana asks.
    Ana’s mom, Milly, stirs more medicine into ice cream and brings it over. But Preston won’t eat.
    For instance, CBD providers commonly tell newly arrived parents that they should reduce the level of an anti-seizure drug called Onfi before starting CBD because the two could have a dangerous interaction. Parents often reduce the medicine without consulting with their doctors. Doctors at Children’s, though, say they haven’t seen conclusive evidence that CBD has an impact on Onfi levels. Meager research makes it impossible to know who is right.
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    The vast majority of CBD products sold online today are derived from the hemp plant. This CBD tends to be extracted from hemp stalks and stems. The quality is enormously variable depending on the quality of extraction and the particular plants used.
    But the study also calls into question parents’ ability to be objective. The doctors found that parents who had moved to Colorado for medical marijuana were much more likely to report that it had helped their children significantly than those who were already living in Colorado — 52 percent compared with 17 percent. In other words, the greater the leap of hope it took to try CBD, the more likely a parent was to see progress.
    Colorado has a special process for kids to be registered as medical marijuana patients under state law. These are the steps:
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    HempMedPX is creating hemp oil rich in CBD or cannabidiol. Unlike THC in marijuana, CBD does not cause the “high” effect. Rather, recent studies indicate “CBD to be well tolerated and safe” and is being tested to treat children with uncontrolled seizures.
    Milly gathered Preston up and sat him on her lap in a chair. He breathed heavily, wheezing in and huffing out. His eyes were shut.
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    A family photograph of Preston as a baby
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