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“We have a special squirt-squirt we need to do, OK? You need to be a big boy,” she said.
Public opinion through the years
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CBD is one of more than 80 active cannabinoid chemicals in the marijuana plant.ii Unlike the main psychoactive cannabinoid in marijuana, tetrahydrocannabinol (THC), CBD does not produce euphoria or intoxication.iii,iv,v Cannabinoids have their effect mainly by interacting with specific receptors on cells in the brain and body: the CB1 receptor, found on neurons and glial cells in various parts of the brain, and the CB2 receptor, found mainly in the body’s immune system. The euphoric effects of THC are caused by its activation of CB1 receptors. CBD has a very low affinity for these receptors (100 fold less than THC) and when it binds it produces little to no effect. There is also growing evidence that CBD acts on other brain signaling systems, and that these actions may be important contributors to its therapeutic effects.ii
“He needs to learn to take it!” Ana says.
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They started with a drug called Depakote when Preston was 3 months old. But the seizures continued — as did the new treatments: Klonopin and Felbatol and Keppra. Zonegran and Topamax and Diamox and Banzel. Vitamin infusions. A special high-fat diet. An implanted electrical nerve stimulator. There were two other drugs not yet fully approved by the federal government that cost hundreds of dollars a month. There was another that has also been suggested for use in executions.
“The big thing that parents are always saying,” Ana said, “is they want their child to say, ‘I love you.’?”
July 25 Preston isn’t feeling well and took to the couch, but sister Sydney decided he needed a little cheering up by playing swoosh with his blanket.
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But no one knows more than anecdotes because Colorado does not track how many families come to treat their children with medical marijuana — although it’s in the low hundreds — or where they go.
One of those extreme cases is out of Orange County. Blake Zika, 22, has suffered from frequent seizures since he was four years old. His illness has left him developmentally challenged.
Preston’s baby book begins with pictures from a sonogram.
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Seven months and 1,600 miles after their journey began, Ana has finally given Preston his first dose of marijuana.
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Even as families flock to the state, few doctors here condone the use of marijuana to treat seizures. And that means the very people on whom families depend for medical advice are often silent when it comes to critical questions about the new treatment.
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