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    The doctor looks at her list. She looks sympathetically at Ana.
    “Tried it,” Ana says.
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    Parents hope to see progress
    The problem is, that while the CBD content can be much higher in cannabis-sourced CBD, the THC level can also be higher. This THC level creates a problem with legality, as THC is considered a dangerous substance which is prohibited in nearly every country. Growers are working hard to maximize the CBD level and minimize the THC level, but the reality is that this plant naturally contains THC, and whether or not man writes a law forbidding it, nature isn’t likely to pay much attention to that law.
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    August 5 Preston hides from his mom as she mixes his medications. He has started using THC with CBD and, aside from being playful with his mother, watched most of “Ghostbusters II.”
    “OK,” Ana says as she fills the capsules. “It’s not going to be pretty.”
    On June 27, 2014 the state legislature passed CBD-oil bills (there was only on nay vote). The legislation calls for a trial study to be conducted by the state's top four universities - UNC, Duke, Wake Forest and East Carolina. Th primarry focus is making making the oil avaialble to youngsters who suffer from seizures. Neurologists are responsble for providing the medicine. Gov. Pat McCrory signed the bill into law into law on July 3, making North Carolina the 10th state to legalize CBD oil.
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    October 16 Preston rides and controls a scooter for the first time by himself in the open space in front of his home.
    The documentary about Charlotte Figi aired the next summer, and by late 2013 — as Preston approached his 12th birthday stuck in the same developmental rut he had been in for his previous nine — the online whispers of a marijuana miracle in Colorado had turned into a roar. One by one, other Dravet children’s parents — with whom Ana had become close friends online but never met in person — began arriving in Colorado, posting hopeful updates on their children’s progress. The hope tugged at her.
    August 8 Milly supports Preston’s head, trying to calm Preston as he comes out of a grand mal seizure. Preston was playing with a water slide in the back yard when he fell and began to seize. A doctor’s appointment the next day reveals a broken bone in his foot.
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    CBD is one of more than 80 active cannabinoid chemicals in the marijuana plant.ii Unlike the main psychoactive cannabinoid in marijuana, tetrahydrocannabinol (THC), CBD does not produce euphoria or intoxication.iii,iv,v Cannabinoids have their effect mainly by interacting with specific receptors on cells in the brain and body: the CB1 receptor, found on neurons and glial cells in various parts of the brain, and the CB2 receptor, found mainly in the body’s immune system. The euphoric effects of THC are caused by its activation of CB1 receptors. CBD has a very low affinity for these receptors (100 fold less than THC) and when it binds it produces little to no effect. There is also growing evidence that CBD acts on other brain signaling systems, and that these actions may be important contributors to its therapeutic effects.ii
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